Easy ecchymosis formation in early childhood, especially the presence of intra-articular and intramuscular spontaneous bleeding, and the presence of a longer-than-expected bleeding history after interventions or trauma are associated with hemophilia. Hemophilia is a rare inherited bleeding disorder that results from the deficiency of factor VIII or IX. Factor VIII deficiency is called Hemophilia A and factor IX deficiency is called Hemophilia B. 85% of all hemophilia patients are Hemophilia A and 15% are hemophilia B.



Hemophilia A has a prevalence of 1 in approximately 5,000 male births. Its diagnosis increases with age. As the baby grows, clinical signs emerge, especially when they start crawling and walking. As the severity of hemophilia increases, the age of diagnosis shifts to earlier periods, and clinical findings are more severe. For this reason, bleeding in patients with mild hemophilia usually occurs after more serious traumas or surgical interventions, causing the diagnosis to be made at an older age.



The severity of the bleeding findings is directly related to the degree of deficiency of factor VIII or IX. Patients with a factor activity of <1% show a "severe hemophilia" clinic, while those between 1-5% show a "moderate hemophilia" clinic, and those with >5% show a "mild hemophilia" clinic.

 


REFERENCES
1.Türk Hematoloji Derneği. Hemofili Tanı ve Tedavi Kılavuzu.Sürüm 1-Temmuz 2011.www.thd.org.tr
2. WFH. Guidelines for the management of hemophilia 2012. Available at: http://www1.wfh.org/publications/files/pdf-1472.pdf [Accessed 20 Jan 2017]
3. History of Bleeding Disorders (April 10,2017) <<https://www.hemophilia.org/Bleeding-Disorders/History-of-Bleeding-Disorders >>