Diffuse Large B-Cell Lymphoma

Diffuse Large B Cell Lymphoma (DLBCL) is a lymphoid malignancy.
DLBCL is the most common lymphoma subtype among non-Hodgkin's lymphomas in adults and DLBCLs constitute 30-58% of non-Hodgkin's lymphomas. It characteristically presents an advanced stage, both in nodal and in extranodal symptomatic disease, with a median age of 60, representing an important disease holding a practical objective of treatment represented by a curative approach. The disease usually presents as a nodal or extranodal mass and systemic symptoms. DLBCL symptoms; fever, night sweats and unexplained weight loss. These are known as ‘B symptoms’. Fatigue and loss of appetite are also quite common.

Excisional lymph node biopsy should be preferred for diagnosis. For more information, please visit

Treatment of diffuse large B-cell lymphoma varies according to the patient's age, stage of the disease and the location of involvement in the body. In early stage DLBCL, radiation therapy is used to stop or slow down organ involvement. If the disease is advanced, chemotherapy and immunotherapy methods can be used together.


  1. “Leticia Quintanilla‐Martinez. The 2016 updated WHO classification of lymphoid neoplasms. Hematological Oncology. 2017;35(S1):37–45.” http://www.kimia-pharma.co/UserFile/Download/hon.2399.pdf [Accessed: July 2023] 

  2. H. Tilly, M. Gomes da Silva et al. Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 26 (Supplement 5): v116–v125, 2015. https://www.annalsofoncology.org/ [Accessed: July 2023]


More diseases

The information provided on this site is not for diagnostic or medical advice, but for informational purposes. If you have or think you have a disease to be treated, consult a specialist physician.

For adverse events related to Roche products,

To contact us about other issues;

Roche Pharma Address: Roche Müstahzarları San A.Ş. Uniq İstanbul Ayazağa Caddesi No:4D/101 34396 Maslak/İstanbul Tel: +90 212 366 90 00


Roche Diagnostics Address: Roche Diagnostics Turkey A.Ş. Esentepe Mah. Kırgülü Sk. Metrocity İş Merkezi D Bl. No: 4/5 34394 Şişli /İstanbul; Tel: +90 212 306 06 06


Supervisors: Bahar Süral & Naz Kocaoğlu

ContactLocationslinkedinfacebooktwitterinstagramyoutubeAbout RocheOur HistoryDiagnostic solutionsFocus areasRoche careersTerms and PoliciesLegal statementCookie policyFor Roche Müstahzarları Sanayi A.Ş.>>For Roche Diagnostics Turkey A.Ş>>