Follicular Lymphoma

Follicular Lymphoma (FL) is the second most common subtype of non-Hodgkin lymphoma.
Follicular Lymphoma (FL) is a type of low grade non-Hodgkin Lymphoma. It is generally asymptomatic and painless in the majority of patients and is usually very slow-growing. For this reason, patients are diagnosed at an advanced stage. Many people have few symptoms and some have none at all. Sometimes follicular lymphoma is noticed during tests for a different health issue. However, follicular lymphoma can be very variable and some people might have faster-growing follicular lymphoma that causes more symptoms.

Excisional lymph node biopsy should be preferred for the diagnostics of FL. Histological classification should be made according to the classification criteria updated by the World Health Organization.

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Although Follicular Lymphoma is generally a slow-progressing disease, it can sometimes develop into aggressive lymphoma. Follicular Lymphoma treatment is planned according to the progression and spread of the disease. The high age at diagnosis and comorbidities are other factors that may affect the treatment decision and treatment options. The FL treatment decision is based not only on disease staging but also on the patient's symptoms.


  1. M. Dreyling , M. Ghielmini. et all. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology vol 32, ıssue 3, P. 298-308, March 2021 [Accessed: July 2023] 

  2. [Accessed: July 2023]


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