As Roche Turkey, we have implemented a social responsibility project with the slogan of “Meme Kanseri Merakına Yenilsin” (Beat Breast Cancer With Curiosity) and reached more than 2 thousand people in total in 6 provinces, in order to answer the questions in mind about the disease with correct answers and to create social awareness.
For more accurate and up-to-date information about the disease, you can follow the @merakinayenilsin Instagram account, which is the social media leg of the project.
For all the questions you may have
Patients with a family history can be candidates for genetic testing. The most common mutations associated with breast cancer are BRCA1 and BRCA2 mutations. Individuals with this mutation are more likely to develop breast cancer.
If there is a palpable mass or a suspicious area, the size of this mass and its relationship with the skin and chest muscles are thoroughly examined. Generally, irregularly demarcated, painless, and firm masses support the presence of a tumor. Other potential signs and symptoms are swelling in one part of the breast, skin irritation, unusual asymmetry, pain and retraction in the nipple, nipple, or rash on the nipple or flaking or discharge. In some cases, the first sign of breast cancer is adenopathy, which usually occurs in the axillary lymph node.
The treatment decision for the patient is made based on the stage and size of the tumor, grade and metastasis potential, HER2 positivity, the patient's physical condition (WHO, Karnofsky scales), the patient's age, preference, and psychological status. Treatment options in breast cancer:
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Globocan 2008. Estimated cancer mortality, all ages: Female. Available at: http://globocan.iarc.fr/.
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Jemal A, et al. Global Cancer Statistics. CA Cancer J Clin 2011; 61:69–90.
American Cancer Society. Breast Cancer. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003090-pdf. Accessed April 2012.
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American Cancer Society. Breast Cancer. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003090-pdf.
Accessed April 2012.
NCCN Guidelines Version 1.2012. Available at: http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. Accessed April 2012.
American Society of Clinical Oncology, "Five Things Physicians and Patients Should Question" (PDF), Choosing Wisely: an initiative of the ABIM Foundation (American Society of Clinical Oncology), retrieved 14 August 2012
Carlson RW, Allred DC, Anderson BO, Burstein HJ, Carter WB, Edge SB, Erban JK, Farrar WB, Goldstein LJ, Gradishar WJ, Hayes DF, Hudis CA, Jahanzeb M, Kiel K, Ljung BM, Marcom PK, Mayer IA, McCormick B, Nabell LM, Pierce LJ, Reed EC, Smith ML, Somlo G, Theriault RL, Topham NS, Ward JH, Winer EP, Wolff AC (2009). "Breast cancer. Clinical practice guidelines in oncology". Journal of the National Comprehensive Cancer Network : JNCCN 7 (2): 122–192.
Holmes MD, Chen WY, Li L, Hertzmark E, Spiegelman D, Hankinson SE (2010). "Aspirin Intake and Survival After Breast Cancer". Journal of Clinical Oncology 28 (9): 1467–72.
Jahanzeb M (August 2008). "Adjuvant trastuzumab therapy for HER2-positive breast cancer". Clin. Breast Cancer 8 (4): 324–33.
Massarut S, Baldassare G, Belleti B, Reccanello S, D'Andrea S, Ezio C, Perin T, Roncadin M, Vaidya JS (2006). "Intraoperative radiotherapy impairs breast cancer cell motility induced by surgical wound fluid"
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Belletti B, Vaidya JS, D'Andrea S, Entschladen F, Roncadin M, Lovat F, Berton S, Perin T, Candiani E, Reccanello S, Veronesi A, Canzonieri V, Trovò MG, Zaenker KS, Colombatti A, Baldassarre G, Massarut S (March 2008). "Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding". Clin. Cancer Res. 14 (5): 1325–32.
Hall PS, McCabe C, Stein RC, Cameron D. J Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer. J Natl Cancer Inst. 2012 Jan 4;104(1):56-66.
The information provided on this site is not for diagnostic or medical advice, but for informational purposes. If you have or think you have a disease to be treated, consult a specialist physician.
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Supervisor: Bahar Süral