It is the second most common non-Hodgkin lymphoma subtype and is the most common type among slow-progressing non-Hodgkin lymphomas. In general, follicular lymphoma follows a painless course and most patients show no symptoms despite the common disease. Therefore, the majority of patients are diagnosed at an advanced stage.



Excisional lymph node biopsy should definitely be preferred for diagnosis. The histological classification should be made in accordance with the classification criteria updated by the World Health Organization in 2008.

You can find classification and staging details.


This disease, which is generally known to have a slow course, can also turn into an aggressive lymphoma. As mentioned before, most of the patients are diagnosed at an advanced stage as they do not show any symptoms. Diagnosis made at an older age and the presence of possible additional diseases are other factors that may affect the treatment decision. Follicular Lymphoma treatment is planned based on the progression and spread of the disease. However, the treatment decision should be based not only on the disease stage but also on the symptoms.



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2- Dreyling, M., et al., Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol, 2014. 25 Suppl 3: p. iii76-82.

3- Bosga-Bouwer AG, van Imhoff GW, Boonstra R, et al. (February 2003). "Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive"Blood 101 (3): 1149–54.

4- Cheson, B.D., et al., Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol, 2014. 32(27): p. 3059-68.

5- Lister TA, Crowther D, Sutcliffe SB; et al. (November 1989). "Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting"J. Clin. Oncol. 7 (11): 1630–6.

6- Lymphoma, Follicular at eMedicine.

7- Sehn LH, Fenske TS, Laport GG. Follicular lymphoma: prognostic factors, conventional therapies, and hematopoietic cell transplantation. Biol Blood Marrow Transplant 2012;18(1 Suppl):82-91.

8- Dreyling M; ESMO Guidelines Working Group. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21(Suppl 5):181-183.