It is the most common non-Hodgkin lymphoma in adults, making up 30-58% of all Non-Hodgkin lymphomas. Although the average age of diagnosis is 70, it is rarely seen in children and young adults. The disease usually presents as a rapidly growing nodal or extranodal mass with systemic symptoms. At times, it manifests itself with fever, weight loss, and night sweats.



Excisional lymph node biopsy should be preferred for diagnosis.

You can find the details of staging and treatment



Chemotherapy and radiotherapy are used. Treatment strategies should be based on the age of the patient, age-appropriate IPI, and applicability of dose-intensive treatment approaches. Special precautions should be taken to avoid tumor lysis syndrome in patients with high tumor burden.




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